TargetMol

APJ receptor agonist 4

Product Code:
 
TAR-T39587
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39587-5mg5mg£1,091.00
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Further Information

Bioactivity:
APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor ( APJ ) with EC 50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease.
CAS:
2135515-67-0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113.