TargetMol

HG-7-85-01

Product Code:
 
TAR-T38653
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38653-5mg5mg£850.00
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Further Information

Bioactivity:
HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl , PDGFRα , Kit , and Src kinases . HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase , KDR and RET with IC 50 s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC 50 >2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis , and inhibition of cell-cycle progression.
CAS:
1258391-13-7
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Ellen Weisberg, et al. Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of BCR-ABL, PDGFRalpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. Blood. 2010 May 27;115(21):4206-16.