TargetMol

JC-171

Product Code:
 
TAR-T38106
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38106-5mg5mg£270.00
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Quantity:
TAR-T38106-1mL1 mL * 10 mM (in DMSO)£291.00
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TAR-T38106-10mg10mg£404.00
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TAR-T38106-50mg50mg£1,066.00
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Quantity:
TAR-T38106-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1].
CAS:
2112809-98-8
Formula:
C16H17ClN2O5S
Molecular Weight:
384.83
Purity:
0.98
SMILES:
O=C(NCCC1=CC=C(S(=O)(NO)=O)C=C1)C2=CC(Cl)=CC=C2OC

References

Chunqing Guo, et al. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201.