TargetMol

(S)-Coriolic acid

Product Code:
 
TAR-T37974
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T37974-1mg1mg£659.00
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TAR-T37974-5mg5mg£1,187.00
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Further Information

Bioactivity:
13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 μM,[1],[2] and down regulates the expression of the IRGpIIb/IIIa receptor.[3]
CAS:
29623-28-7
Formula:
C18H32O3
Molecular Weight:
296.5
Pathway:
DNA Damage/DNA Repair|Metabolism
Purity:
0.98
SMILES:
CCCCC[C@H](O)/C=C/C=CCCCCCCCC(O)=O
Target:
PPAR|Lipoxygenase|Mitochondrial Metabolism

References

Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349. Yuan H, et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax. 2010;65(4):321-326. Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-?B signaling pathway. J Invest Dermatol. 2011;131(3):604-612. Buchanan MR, et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. J Biol Chem. 1985;260(30):16056-16059. Honn KV, et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins. 1992;44(5):413-429.