TargetMol

5-Ethynyluridine

Product Code:
 
TAR-T36971
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36971-5mg5mg£108.00
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Quantity:
TAR-T36971-1mL1 mL * 10 mM (in DMSO)£112.00
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Quantity:
TAR-T36971-10mg10mg£135.00
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TAR-T36971-25mg25mg£189.00
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Quantity:
TAR-T36971-50mg50mg£282.00
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Quantity:
TAR-T36971-100mg100mg£377.00
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Quantity:
TAR-T36971-200mg200mg£531.00
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  • Further Information
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Further Information

Bioactivity:
5-Ethynyluridine can be used to label newly synthesized RNA. This approach, named capture of the newly transcribed RNA interactome using click chemistry (RICK), systematically captures proteins bound to a wide range of RNAs, including nascent RNAs and traditionally neglected nonpolyadenylated RNAs.
CAS:
69075-42-9
Formula:
C11H12N2O6
Molecular Weight:
268.225
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
1
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#C)c(=O)[nH]c1=O
Target:
Nucleoside Antimetabolite/Analog

References

Bao X, et al. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018 Mar;15(3):213-220. Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94.