TargetMol

H-Leu-Leu-OMe . HBr

Product Code:
 
TAR-T36879L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T36879L-5mg5mg£111.00
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TAR-T36879L-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-T36879L-10mg10mg£131.00
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TAR-T36879L-25mg25mg£179.00
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TAR-T36879L-50mg50mg£229.00
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TAR-T36879L-100mg100mg£309.00
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Quantity:
TAR-T36879L-200mg200mg£437.00
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Further Information

Bioactivity:
H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential.
CAS:
0
Formula:
C15H31BrN2O5
Molecular Weight:
399.32
Purity:
0.9891
SMILES:
CC(O)=O.O=C(OC)[C@@H](CC(C)C)NC([C@@H](N)CC(C)C)=O.Br

References

Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7.