TargetMol

Setipiprant

Product Code:
 
TAR-T3520
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3520-5mg5mg£91.00
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TAR-T3520-1mL1 mL * 10 mM (in DMSO)£95.00
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TAR-T3520-10mg10mg£102.00
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TAR-T3520-25mg25mg£128.00
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TAR-T3520-50mg50mg£165.00
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TAR-T3520-100mg100mg£222.00
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TAR-T3520-200mg200mg£294.00
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Further Information

Bioactivity:
Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.
CAS:
866460-33-5
Formula:
C24H19FN2O3
Molecular Weight:
402.425
Pathway:
GPCR/G Protein; Endocrinology/Hormones; Immunology/Inflammation
Purity:
0.9971
SMILES:
OC(=O)Cn1c2CCN(Cc2c2cc(F)ccc12)C(=O)c1cccc2ccccc12
Target:
GPR; Prostaglandin Receptor

References

Hoch M., et al. Disposition and metabolism of setipiprant, a selective oral CRTH2 antagonist, in humans. Drugs R D. 2013 Dec;13(4):253-69. Diamant Z., et al. Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics. Clin Exp Allergy. 2014 Aug;44(8):1044-52.