TargetMol

TAK-259 HCl

Product Code:
 
TAR-T34774
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34774-5mg5mg£930.00
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TAR-T34774-50mg50mg£1,821.00
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TAR-T34774-100mg100mg£2,319.00
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Further Information

Bioactivity:
TAK-259 is a novel, selective, and orally active α1D adrenergic receptor antagonist (α1D, Ki = 1.1 nM) that represents a promising new therapeutic agent for the treatment of symptoms of OAB. It has an anti-frequency effect and reduces the burden of the human Ether-a-Go-Go-Related gene (HERG).
CAS:
1192347-42-4
Formula:
C14H14Cl3N3O3S
Molecular Weight:
410.69
Purity:
0.98
SMILES:
Cl.CS(=O)(=O)c1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N

References

Sakauchi N, Kohara Y, Sato A, Suzaki T, Imai Y, Okabe Y, Imai S, Saikawa R, Nagabukuro H, Kuno H, Fujita H, Kamo I, Yoshida M. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259), as a Novel, Selective, and Orally Active ?1D Adrenoceptor Antagonist with Anti-urinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. J Med Chem. 2016 Mar 8. [Epub ahead of print] PubMed PMID: 26954848.