TargetMol

RO5203648 HCl

Product Code:
 
TAR-T34374
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34374-1mg1mg£130.00
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TAR-T34374-1mL1 mL * 10 mM (in DMSO)£205.00
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TAR-T34374-5mg5mg£213.00
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TAR-T34374-10mg10mg£322.00
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TAR-T34374-25mg25mg£499.00
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TAR-T34374-50mg50mg£687.00
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Quantity:
TAR-T34374-100mg100mg£938.00
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This product comes from: United States.
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Further Information

Bioactivity:
RO5203648 is a TAAR1 partial agonist (trace amine related receptor 1) with high affinity and potency, high selectivity for other targets, and favorable pharmacokinetic properties. RO5203648 has obvious antipsychotic and antidepressant-like activities as well as potential anti-anxiety-like properties.
CAS:
1043491-54-8
Formula:
C9H10Cl4N2O
Molecular Weight:
303.99
Purity:
0.98
SMILES:
Cl.Cl.NC1=N[C@H](CO1)c1ccc(Cl)c(Cl)c1

References

Cotter R, et al. The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects. Front Neurosci. 2015 Feb 13;9:39. Pei Y, et al. Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:70-5. Pei Y, et al. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology. 2014 Sep;39(10):2299-308. Revel FG, et al. Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol Psychiatry. 2012 Dec 1;72(11):934-42.