TargetMol

RAPTA-C

Product Code:
 
TAR-T34262
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34262-5mg5mg£850.00
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Further Information

Bioactivity:
RAPTA-C can induce apoptosis of EAC cells by mitochondrial and p53-JNK pathways.
CAS:
372948-28-2
Formula:
C24H36Cl2N5PRu
Molecular Weight:
597.53
Purity:
0.98
SMILES:
Cl[Ru]Cl.c1[nH+][nH]c2ccccc12.CC(C)c1ccc(C)cc1.C[P-]12CN3CN(CN(C3)C1)C2

References

Biancalana L, Zacchini S, Ferri N, Lupo MG, Pampaloni G, Marchetti F. Tuning the cytotoxicity of ruthenium(ii) para-cymene complexes by mono-substitution at a triphenylphosphine/phenoxydiphenylphosphine ligand. Dalton Trans. 2017 Dec 21;46(47):16589-16604. doi: 10.1039/c7dt03385k. Epub 2017 Nov 22. PubMed PMID: 29164209. Batchelor LK, P?unescu E, Soudani M, Scopelliti R, Dyson PJ. Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes. Inorg Chem. 2017 Aug 21;56(16):9617-9633. doi: 10.1021/acs.inorgchem.7b01082. Epub 2017 Jul 31. PubMed PMID: 28758743. Davey GE, Adhireksan Z, Ma Z, Riedel T, Sharma D, Padavattan S, Rhodes D, Ludwig A, Sandin S, Murray BS, Dyson PJ, Davey CA. Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation. Nat Commun. 2017 Nov 17;8(1):1575. doi: 10.1038/s41467-017-01680-4. PubMed PMID: 29146919; PubMed Central PMCID: PMC5691193. Holtkamp HU, Movassaghi S, Morrow SJ, Kubanik M, Hartinger CG. Metallomic study on the metabolism of RAPTA-C and cisplatin in cell culture medium and its impact on cell accumulation. Metallomics. 2018 Mar 1;10(3):455-462. doi: 10.1039/c8mt00024g. Epub 2018 Feb 27. PubMed PMID: 29484339.