TargetMol

Posizolid

Product Code:
 
TAR-T34115
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34115-5mg5mg£850.00
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Further Information

Bioactivity:
Posizolid(AZD-5847,AZD-2563) is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections.
CAS:
252260-02-9
Formula:
C21H21F2N3O7
Molecular Weight:
465.41
Purity:
0.98
SMILES:
OC[C@H](O)C(=O)N1CCC(=CC1)c1c(F)cc(cc1F)N1C[C@H](COc2ccon2)OC1=O

References

Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, Via LE, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, Barry CE 3rd, Flynn JL. PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis. Sci Transl Med. 2014 Dec 3;6(265):265ra167. doi: 10.1126/scitranslmed.3009500. PubMed PMID: 25473035. Tasneen R, Betoudji F, Tyagi S, Li SY, Williams K, Converse PJ, Dartois V, Yang T, Mendel CM, Mdluli KE, Nuermberger EL. Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):270-7. doi: 10.1128/AAC.01691-15. PubMed PMID: 26503656. Jadhavar PS, Vaja MD, Dhameliya TM, Chakraborti AK. Oxazolidinones as Anti-tubercular Agents: Discovery, Development and Future Perspectives. Curr Med Chem. 2015;22(38):4379-97. PubMed PMID: 26549430. Kumar D, Negi B, Rawat DS. The anti-tuberculosis agents under development and the challenges ahead. Future Med Chem. 2015 Oct;7(15):1981-2003. doi: 10.4155/fmc.15.128. Epub 2015 Oct 27. PubMed PMID: 26505682.