TargetMol

PAPS

Product Code:
 
TAR-T33880
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
PAPS is a product of mitosomal sulfate activation which is translocated to the cytosol, then becomes a substrate for SULTs.
CAS:
482-67-7
Formula:
C10H15N5O13P2S
Molecular Weight:
507.26
Purity:
0.98
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O

References

Kowalska J, Osowniak A, Zuberek J, Jemielity J. Synthesis of nucleoside phosphosulfates. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3661-4. doi: 10.1016/j.bmcl.2012.04.039. Epub 2012 Apr 20. PubMed PMID: 22572581. Dong D, Ako R, Wu B. Crystal structures of human sulfotransferases: insights into the mechanisms of action and substrate selectivity. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):635-46. doi: 10.1517/17425255.2012.677027. Epub 2012 Apr 19. Review. PubMed PMID: 22512672. Cook I, Wang T, Falany CN, Leyh TS. A nucleotide-gated molecular pore selects sulfotransferase substrates. Biochemistry. 2012 Jul 17;51(28):5674-83. Epub 2012 Jun 29. PubMed PMID: 22703301; PubMed Central PMCID: PMC3448010. Rohn KJ, Cook IT, Leyh TS, Kadlubar SA, Falany CN. Potent inhibition of human sulfotransferase 1A1 by 17?-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity. Drug Metab Dispos. 2012 Aug;40(8):1588-95. doi: 10.1124/dmd.112.045583. Epub 2012 May 16. PubMed PMID: 22593037; PubMed Central PMCID: PMC3400793.