TargetMol

NBI-34041

Product Code:
 
TAR-T33607
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33607-5mg5mg£1,171.00
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TAR-T33607-50mg50mg£2,303.00
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Quantity:
TAR-T33607-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
NBI-34041 is an effective and high-affinity CRF1 receptor antagonist that effectively reduces endocrine responses to CRF(1) receptor-mediated pharmacological and behavioral challenges.
CAS:
268545-87-5
Formula:
C22H26Cl2N4
Molecular Weight:
417.38
Purity:
0.98
SMILES:
CCCC(CCC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23

References

Ising M, Zimmermann US, K?nzel HE, Uhr M, Foster AC, Learned-Coughlin SM, Holsboer F, Grigoriadis DE. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. Epub 2007 Feb 7. PubMed PMID: 17287823. Steckler T. Developing small molecule nonpeptidergic drugs for the treatment of anxiety disorders: is the challenge still ahead? Curr Top Behav Neurosci. 2010;2:415-28. Review. PubMed PMID: 21309119. Ising M, Holsboer F. CRH-sub-1 receptor antagonists for the treatment of depression and anxiety. Exp Clin Psychopharmacol. 2007 Dec;15(6):519-28. doi: 10.1037/1064-1297.15.6.519. Review. PubMed PMID: 18179304. Holsboer F, Ising M. Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 2008 Apr 7;583(2-3):350-7. doi: 10.1016/j.ejphar.2007.12.032. Epub 2008 Jan 24. Review. PubMed PMID: 18272149.