TargetMol

ms2i6A

Product Code:
 
TAR-T33511
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33511-5mg5mg£4,769.00
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Further Information

Bioactivity:
ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.
CAS:
20859-00-1
Formula:
C16H23N5O4S
Molecular Weight:
381.45
Purity:
0.98
SMILES:
[H][C@]1(CO)O[C@@]([H])(n2cnc3c(NCC=C(C)C)nc(SC)nc23)[C@]([H])(O)[C@]1([H])O

References

Connolly DM, Winkler ME. Structure of Escherichia coli K-12 miaA and characterization of the mutator phenotype caused by miaA insertion mutations. J Bacteriol. 1991 Mar;173(5):1711-21. PubMed PMID: 1999389; PubMed Central PMCID: PMC207322. Vacher J, Grosjean H, Houssier C, Buckingham RH. The effect of point mutations affecting Escherichia coli tryptophan tRNA on anticodon-anticodon interactions and on UGA suppression. J Mol Biol. 1984 Aug 5;177(2):329-42. PubMed PMID: 6379198. D?az I, Ehrenberg M. ms2i6A deficiency enhances proofreading in translation. J Mol Biol. 1991 Dec 20;222(4):1161-71. PubMed PMID: 1762149. Fakruddin M, Wei FY, Emura S, Matsuda S, Yasukawa T, Kang D, Tomizawa K. Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. Nucleic Acids Res. 2017 Nov 16;45(20):11954-11961. doi: 10.1093/nar/gkx819. PubMed PMID: 28981754; PubMed Central PMCID: PMC5714233.