TargetMol

Metyrapol

Product Code:
 
TAR-T33370
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33370-5mg5mg£850.00
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TAR-T33370-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T33370-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.
CAS:
17159-42-1
Formula:
C14H16N2O
Molecular Weight:
228.295
Purity:
0.98
SMILES:
CC(C)(C(O)c1cccnc1)c1cccnc1

References

Berger ML, Hammerschmidt F, Qian R, Hahner S, Schirbel A, Stichelberger M, Schibli R, Yu J, Arion VB, Woschek A, ?hler E, Zolle IM. [(3)H]metyrapol and 4-[(131)i]iodometomidate label overlapping, but not identical, binding sites on rat adrenal membranes. Mol Pharm. 2013 Mar 4;10(3):1119-30. doi: 10.1021/mp3006227. Epub 2013 Feb 20. PubMed PMID: 23343186. Nagamine S, Horisaka E, Fukuyama Y, Maetani K, Matsuzawa R, Iwakawa S, Asada S. Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11 beta-hydroxylase in the rat. Biol Pharm Bull. 1997 Feb;20(2):188-92. PubMed PMID: 9057984. Cassiano NM, Cass QB, Degani AL, Wainer IW. Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography. Chirality. 2002 Oct;14(9):731-5. PubMed PMID: 12237834. Hotham NJ, Ilett KF, Hackett LP, Morton MR, Muller P, Hague WM. Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk. J Hum Lact. 2009 Nov;25(4):451-4. doi: 10.1177/0890334409345496. Epub 2009 Sep 16. PubMed PMID: 19759353.