TargetMol

Melarsoprol

Product Code:
 
TAR-T33278
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33278-5mg5mg£850.00
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TAR-T33278-50mg50mg£1,661.00
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TAR-T33278-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Melarsoprol, an organoarsenic compound, can be used to treat trypanosomiasis (human African sleeping sickness).
CAS:
494-79-1
Formula:
C12H15AsN6OS2
Molecular Weight:
398.33
Purity:
0.98
SMILES:
Nc1nc(N)nc(Nc2ccc(cc2)[As]2SCC(CO)S2)n1

References

Raber G, Raber T, Raml R, Murko M, Magnes C, Francesconi KA. Determination of the trypanocidal drug melarsoprol and its conversion products in biological fluids with HPLC-ICPMS/ESMS. Talanta. 2013 Nov 15;116:876-81. doi: 10.1016/j.talanta.2013.07.066. Epub 2013 Aug 7. PubMed PMID: 24148488. Baumann A, Pfeifer T, Melles D, Karst U. Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis. Anal Bioanal Chem. 2013 Jun;405(15):5249-58. doi: 10.1007/s00216-013-6929-7. Epub 2013 Apr 4. PubMed PMID: 23552974. Pyana Pati P, Van Reet N, Mumba Ngoyi D, Ngay Lukusa I, Karhemere Bin Shamamba S, B?scher P. Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2014 Oct 2;8(10):e3212. doi: 10.1371/journal.pntd.0003212. eCollection 2014 Oct. PubMed PMID: 25275572; PubMed Central PMCID: PMC4183442. Kennedy PG. An alternative form of melarsoprol in sleeping sickness. Trends Parasitol. 2012 Aug;28(8):307-10. doi: 10.1016/j.pt.2012.05.003. Epub 2012 Jun 15. PubMed PMID: 22704910.