TargetMol

LM-1685

Product Code:
 
TAR-T32824
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32824-1mg1mg£352.00
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TAR-T32824-5mg5mg£736.00
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TAR-T32824-10mg10mg£978.00
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TAR-T32824-25mg25mg£1,348.00
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TAR-T32824-50mg50mg£1,661.00
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TAR-T32824-100mg100mg£2,079.00
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Quantity:
TAR-T32824-500mg500mg£4,006.00
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This product comes from: United States.
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Further Information

Bioactivity:
LM-1685 is an effective selective inhibitor of COX-2 in human monocytes (IC50 = 650 nM) and whole blood (IC50 = 4.3 μM).
CAS:
416901-58-1
Formula:
C18H16ClNO4S
Molecular Weight:
377.84
Pathway:
Neuroscience|Immunology/Inflammation
Purity:
0.98
SMILES:
COC(=O)c1cc2cc(ccc2n1Cc1ccc(Cl)cc1)S(C)(=O)=O
Target:
COX

References

1. Huang KH, Kuo KL, Chen SC, Weng TI, Chuang YT, Tsai YC, Pu YS, Chiang CK, Liu SH. Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PLoS One. 2012;7(3):e33615. doi: 10.1371/journal.pone.0033615. Epub 2012 Mar 16. PubMed PMID: 22438966; PubMed Central PMCID: PMC3306428. 2. Collins C, Klausner AP, Herrick B, Koo HP, Miner AS, Henderson SC, Ratz PH. Potential for control of detrusor smooth muscle spontaneous rhythmic contraction by cyclooxygenase products released by interstitial cells of Cajal. J Cell Mol Med. 2009 Sep;13(9B):3236-50. doi: 10.1111/j.1582-4934.2009.00714.x. Epub 2009 Feb 20. PubMed PMID: 19243470; PubMed Central PMCID: PMC4516481. 3. Winters ME, Mehta AI, Petricoin EF 3rd, Kohn EC, Liotta LA. Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. Cancer Res. 2005 May 1;65(9):3853-60. PubMed PMID: 15867384. 4. Palomer A, Cabr? F, Pascual J, Campos J, Trujillo MA, Entrena A, Gallo MA, Garc?a L, Maule?n D, Espinosa A. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem. 2002 Mar 28;45(7):1402-11. PubMed PMID: 11906281.