TargetMol

JWB1-84-1 3HCl

Product Code:
 
TAR-T32330
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32330-5mg5mg£850.00
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TAR-T32330-50mg50mg£1,661.00
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Quantity:
TAR-T32330-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
JWB1-84-1 3HCl, as a neuroprotective agent, can act by improving cognitive performances in a transgenic mouse model of AD.
CAS:
491878-69-4
Formula:
C12H22Cl3N3O
Molecular Weight:
330.68
Purity:
0.98
SMILES:
Cl.Cl.Cl.OCCN1CCN(Cc2cccnc2)CC1

References

1. Keowkase R, Aboukhatwa M, Adam BL, Beach JW, Terry AV Jr, Buccafussco JJ, Luo Y. Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans. Mol Neurodegener. 2010 Dec 16;5:59. doi: 10.1186/1750-1326-5-59. PubMed PMID: 21162742; PubMed Central PMCID: PMC3017027. 2. Buccafusco JJ, Beach JW, Terry AV Jr. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Pharmacol Exp Ther. 2009 Feb;328(2):364-70. doi: 10.1124/jpet.108.145292. Epub 2008 Nov 20. Review. PubMed PMID: 19023041; PubMed Central PMCID: PMC2682277. 3. Sood A, Warren Beach J, Webster SJ, Terry AV, Buccafusco JJ. The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys. Neuropharmacology. 2007 Oct;53(5):588-600. Epub 2007 Jul 14. PubMed PMID: 17698153. 4. Buccafusco JJ. Neuronal nicotinic receptor subtypes: defining therapeutic targets. Mol Interv. 2004 Oct;4(5):285-95. Review. PubMed PMID: 15471911.