TargetMol

GSK299423

Product Code:
 
TAR-T32008
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32008-5mg5mg£850.00
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Further Information

Bioactivity:
GSK299423 (GlaxoSmithKline 299423) is an antibiotic that may have therapeutic effect in patients infected with bacteria expressing New Delhi metal-β-lactamase. Antibiotics inhibit the topoisomerases that the bacteria need to replicate.
CAS:
1352149-24-6
Formula:
C25H27N5O2S
Molecular Weight:
461.58
Purity:
0.98
SMILES:
COc1ccc2ncc(C#N)c(CCN3CCC(CC3)NCc3cc4SCOc4cn3)c2c1

References

1. Mudeppa DG, Kumar S, Kokkonda S, White J, Rathod PK. Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION. J Biol Chem. 2015 Aug 14;290(33):20313-24. doi: 10.1074/jbc.M115.639039. Epub 2015 Jun 8. PubMed PMID: 26055707; PubMed Central PMCID: PMC4536438. 2. Vos SM, Lyubimov AY, Hershey DM, Schoeffler AJ, Sengupta S, Nagaraja V, Berger JM. Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev. 2014 Jul 1;28(13):1485-97. doi: 10.1101/gad.241984.114. PubMed PMID: 24990966; PubMed Central PMCID: PMC4083091. 3. Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen D, Lagrutta A, Bradley P, Lu J, Patel S, Rickert KW, Smith RF, Soisson S, Wei C, Fukuda H, Kishii R, Takei M, Fukuda Y. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. ACS Med Chem Lett. 2014 Mar 12;5(5):609-14. doi: 10.1021/ml500069w. eCollection 2014 May 8. PubMed PMID: 24900889; PubMed Central PMCID: PMC4027601. 4. Bax BD, Chan PF, Eggleston DS, Fosberry A, Gentry DR, Gorrec F, Giordano I, Hann MM, Hennessy A, Hibbs M, Huang J, Jones E, Jones J, Brown KK, Lewis CJ, May EW, Saunders MR, Singh O, Spitzfaden CE, Shen C, Shillings A, Theobald AJ, Wohlkonig A, Pearson ND, Gwynn MN. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4. PubMed PMID: 20686482.