TargetMol

GNE-9822

Product Code:
 
TAR-T31982
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31982-5mg5mg£430.00
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TAR-T31982-50mg50mg£1,589.00
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Quantity:
TAR-T31982-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-9822 is a potent selective ITK inhibitor that shows favorable ADME properties in preclinical species.
CAS:
1557232-32-2
Formula:
C24H32N6O
Molecular Weight:
420.561
Purity:
0.98
SMILES:
CN(C)CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3CC(C)(C)CCc23)cn1

References

1. Burch JD, Lau K, Barker JJ, Brookfield F, Chen Y, Chen Y, Eigenbrot C, Ellebrandt C, Ismaili MH, Johnson A, Kordt D, MacKinnon CH, McEwan PA, Ortwine DF, Stein DB, Wang X, Winkler D, Yuen PW, Zhang Y, Zarrin AA, Pei Z. Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J Med Chem. 2014 Jul 10;57(13):5714-27. doi: 10.1021/jm500550e. Epub 2014 Jun 27. PubMed PMID: 24918870.