TargetMol

Erythrofuranosyladenine

Product Code:
 
TAR-T31672
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31672-5mg5mg£850.00
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TAR-T31672-50mg50mg£1,661.00
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Quantity:
TAR-T31672-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Erythrofuranosyladenine(9-beta-D-Erythrofuranosyladenine, ETA) is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase?selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.
CAS:
17019-46-4
Formula:
C9H11N5O3
Molecular Weight:
237.219
Purity:
0.98
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1OC[C@@H](O)[C@H]1O

References

1. Batova A, Cottam H, Yu J, Diccianni MB, Carrera CJ, Yu AL. EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Blood. 2006 Feb 1;107(3):898-903. Epub 2005 Oct 18. PubMed PMID: 16234352; PubMed Central PMCID: PMC1895892. 2. Lerner LM. Preparation of nucleosides via isopropylidene sugar derivatives. IV. Synthesis of 9-alpha and 9-beta-L-erythrofuranosyladenine. J Org Chem. 1969 Jan;34(1):101-3. PubMed PMID: 5768222. 3. Marc? S, Balagu? O, Colomo L, Martinez A, H?ller S, Villamor N, Bosch F, Ott G, Rosenwald A, Leoni L, Esteller M, Fraga MF, Montserrat E, Colomer D, Campo E. Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clin Cancer Res. 2006 Jun 15;12(12):3754-61. PubMed PMID: 16778103.