TargetMol

PS 48

Product Code:
 
TAR-T3163
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3163-5mg5mg£108.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T3163-1mL1 mL * 10 mM (in DMSO)£109.00
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Quantity:
TAR-T3163-10mg10mg£122.00
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Quantity:
TAR-T3163-25mg25mg£168.00
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Quantity:
TAR-T3163-50mg50mg£213.00
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Quantity:
TAR-T3163-100mg100mg£286.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
CAS:
1180676-32-7
Formula:
C17H15ClO2
Molecular Weight:
286.76
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
OC(=O)C=C(CCc1ccc(Cl)cc1)c1ccccc1
Target:
PDK

References

1. Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13(10):1266-1275. 2. Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.