TargetMol

Cyclochlorotine

Product Code:
 
TAR-T31134
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31134-5mg5mg£850.00
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Further Information

Bioactivity:
Cyclochlorotine is a mycotoxin produced by Penicillium insularum, which can cause liver injury and has carcinogenic properties.
CAS:
12663-46-6
Formula:
C24H31Cl2N5O7
Molecular Weight:
572.44
Purity:
0.98
SMILES:
CC[C@H]1NC(=O)[C@@H]2[C@H](Cl)[C@H](Cl)CN2C(=O)[C@@H](CO)NC(=O)C[C@@H](NC(=O)[C@H](CO)NC1=O)c1ccccc1

References

1. Schafhauser T, Kirchner N, Kulik A, Huijbers MM, Flor L, Caradec T, Fewer DP, Gross H, Jacques P, Jahn L, Jokela J, Lecl?re V, Ludwig-M?ller J, Sivonen K, van Berkel WJ, Weber T, Wohlleben W, van P?e KH. The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum'). Environ Microbiol. 2016 Nov;18(11):3728-3741. doi: 10.1111/1462-2920.13294. Epub 2016 Jun 27. PubMed PMID: 26954535. 2. Schafhauser T, Wibberg D, R?ckert C, Winkler A, Flor L, van P?e KH, Fewer DP, Sivonen K, Jahn L, Ludwig-M?ller J, Caradec T, Jacques P, Huijbers MM, van Berkel WJ, Weber T, Wohlleben W, Kalinowski J. Draft genome sequence of Talaromyces islandicus ("Penicillium islandicum") WF-38-12, a neglected mold with significant biotechnological potential. J Biotechnol. 2015 Oct 10;211:101-2. doi: 10.1016/j.jbiotec.2015.07.004. Epub 2015 Jul 18. PubMed PMID: 26197417. 3. Wang L, Li MD, Cao PP, Zhang CF, Huang F, Xu XH, Liu BL, Zhang M. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9. doi: 10.1016/j.cbi.2014.09.003. Epub 2014 Sep 16. PubMed PMID: 25219577. 4. Mizutani K, Hirasawa Y, Sugita-Konishi Y, Mochizuki N, Morita H. Structural and conformational analysis of hydroxycyclochlorotine and cyclochlorotine, chlorinated cyclic peptides from Penicillium islandicum. J Nat Prod. 2008 Jul;71(7):1297-300. doi: 10.1021/np800150m. Epub 2008 Jun 18. PubMed PMID: 18558744.