TargetMol

CP-432

Product Code:
 
TAR-T31054
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31054-5mg5mg£1,010.00
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TAR-T31054-50mg50mg£1,982.00
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TAR-T31054-100mg100mg£2,560.00
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Further Information

Bioactivity:
CP-432 (CP-734432) is an EP4 prostaglandin agonist for the treatment of glaucoma and ocular hypertension.
CAS:
431990-08-8
Formula:
C23H26F3NO4S
Molecular Weight:
469.52
Purity:
0.98
SMILES:
O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)C(F)(F)F

References

1. Hu KZ, Ma J, Qiu S, Zheng X, Huang PQ. SmI2-mediated intermolecular coupling of ?-lactam N-?-radicals with activated alkenes: asymmetric synthesis of 11-hydroxylated analogues of the lead compounds CP-734432 and PF-04475270. J Org Chem. 2013 Mar 1;78(5):1790-801. doi: 10.1021/jo301277n. Epub 2012 Aug 14. PubMed PMID: 22853560. 2. Luu KT, Zhang EY, Prasanna G, Xiang C, Anderson S, Fortner J, Vicini P. Pharmacokinetic-pharmacodynamic and response sensitization modeling of the intraocular pressure-lowering effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin- 1-yl]propyl}thiophene-2-carboxylate (PF-04475270). J Pharmacol Exp Ther. 2009 Nov;331(2):627-35. doi: 10.1124/jpet.109.157800. Epub 2009 Aug 18. PubMed PMID: 19690190. 3. Prasanna G, Fortner J, Xiang C, Zhang E, Carreiro S, Anderson S, Sartnurak S, Wu G, Gukasyan H, Niesman M, Nair S, Rui E, Lafontaine J, Almaden CD, Wells P, Krauss A. Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models. Exp Eye Res. 2009 Nov;89(5):608-17. doi: 10.1016/j.exer.2009.05.002. Epub 2009 May 13. PubMed PMID: 19445930.