TargetMol

Bulaquine

Product Code:
 
TAR-T30612
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30612-5mg5mg£850.00
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TAR-T30612-50mg50mg£1,661.00
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Quantity:
TAR-T30612-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Bulaquine is a derivative of 8-aminoquinoline and has effective activity against the liver stage of plasmodium falciparum and the dormant bodies of Plasmodium vivax and Plasmodium ovale.
CAS:
79781-00-3
Formula:
C21H27N3O3
Molecular Weight:
369.465
Purity:
0.98
SMILES:
COc1cc(NC(C)CCCNC(C)=C2CCOC2=O)c2ncccc2c1

References

1. Dwivedi AK, Saxena D, Singh S. HPLC and HPTLC assays for the antimalarial agents chloroquine, primaquine and bulaquine. J Pharm Biomed Anal. 2003 Nov 24;33(4):851-8. PubMed PMID: 14623615. 2. Mehrotra N, Lal J, Puri SK, Madhusudanan KP, Gupta RC. In Vitro and In Vivo pharmacokinetic studies of bulaquine (analogue of primaquine), a novel antirelapse antimalarial, in rat, rabbit and monkey--highlighting species similarities and differences. Biopharm Drug Dispos. 2007 Jul;28(5):209-27. PubMed PMID: 17410524. 3. Noel S, Sharma S, Shankar R, Rath SK. Identification of differentially expressed genes after acute exposure to bulaquine (CDRI 80/53) in mice liver. Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):522-9. doi: 10.1111/j.1742-7843.2008.00279.x. Epub 2008 Jul 18. PubMed PMID: 18684221. 4. Gogtay NJ, Kamtekar KD, Dalvi SS, Mehta SS, Chogle AR, Aigal U, Kshirsagar NA. A randomized, parallel study of the safety and efficacy of 45 mg primaquine versus 75 mg bulaquine as gametocytocidal agents in adults with blood schizonticide-responsive uncomplicated falciparum malaria [ISCRTN50134587]. BMC Infect Dis. 2006 Feb 1;6:16. PubMed PMID: 16448575; PubMed Central PMCID: PMC1389708.