TargetMol

BMS-262084

Product Code:
 
TAR-T30510
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30510-5mg5mg£457.00
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Quantity:
TAR-T30510-50mg50mg£2,303.00
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Quantity:
TAR-T30510-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
BMS-262084 is a potent selective β-lactam trypsin inhibitor with therapeutic potential in the treatment of asthma.
CAS:
253174-92-4
Formula:
C18H31N7O5
Molecular Weight:
425.49
Purity:
0.98
SMILES:
CC(C)(C)NC(=O)N1CCN(CC1)C(=O)N1[C@@H]([C@@H](CCCNC(N)=N)C1=O)C(O)=O

References

1. Slusarchyk WA, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Sutton JC, Treuner U, Zahler R, Zhao G, Bisacchi GS. Synthesis of potent and highly selective inhibitors of human tryptase. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8. PubMed PMID: 12372541. 2. Qian X, Zheng B, Burke B, Saindane MT, Kronenthal DR. A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor. J Org Chem. 2002 May 31;67(11):3595-600. PubMed PMID: 12027669. 3. Kamath AV, Morrison RA, Harper TW, Lan SJ, Marino AM, Chong S. Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprotein efflux. J Pharm Sci. 2005 May;94(5):1115-23. PubMed PMID: 15793809.