TargetMol

Aptazapine maleate

Product Code:
 
TAR-T30108
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30108-5mg5mg£1,091.00
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TAR-T30108-50mg50mg£2,143.00
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Quantity:
TAR-T30108-100mg100mg£2,801.00
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  • Further Information
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Further Information

Bioactivity:
Aptazapine (CGS 7525A) is a tetracyclic antidepressant (TECA) that is a potent α2-adrenergic receptor antagonist and has also been shown to act as a 5-HT2 receptor antagonist and an H1 receptor reverse agonist, both for serotonin reuptake or norepinephrine.
CAS:
71576-41-5
Formula:
C20H23N3O4
Molecular Weight:
369.421
Purity:
0.98
SMILES:
OC(=O)C=C/C(O)=O.CN1CCN2C(C1)c1cccn1Cc1ccccc21

References

1. Cirilli R, Orlando V, Ferretti R, Turchetto L, Silvestri R, De Martino G, La Torre F. Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and immobilized polysaccharide-based chiral stationary phases. Chirality. 2006 Aug;18(8):621-32. PubMed PMID: 16715514. 2. Nishino S, Haak L, Shepherd H, Guilleminault C, Sakai T, Dement WC, Mignot E. Effects of central alpha-2 adrenergic compounds on canine narcolepsy, a disorder of rapid eye movement sleep. J Pharmacol Exp Ther. 1990 Jun;253(3):1145-52. PubMed PMID: 1972749. 3. Gower AJ, Broekkamp CL, Rijk HW, Van Delft AM. Pharmacological evaluation of in vivo tests for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770. Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:185-201. PubMed PMID: 2896489. 4. Gerhardt S, Liebman JM. Self-regulation of ICSS duration: effects of anxiogenic substances, benzodiazepine antagonists and antidepressants. Pharmacol Biochem Behav. 1985 Jan;22(1):71-6. PubMed PMID: 2858109.