Apratoxin A

Product Code:

TAR-T30104

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T30104-5mg

5mg

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Further Information

Bioactivity:

Apratoxin A is a potent cytotoxin isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont.

CAS:

350791-64-9

Formula:

C45H69N5O9S

Molecular Weight:

856.13

Purity:

0.98

SMILES:

COc1ccc(C[C@H](NC(=O)C(C)=C[C@H]2CSC(=N2)[C@@H](C)[C@@H](O)C[C@H](C)C[C@H](O)C(C)(C)C)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@H]2[C@@H](C)C(C)OC(=O)[C@@H]3CCCN3C2=O)cc1

Documents

References

1. Doi T. Synthesis of the biologically active natural product cyclodepsipeptides apratoxin A and its analogues. Chem Pharm Bull (Tokyo). 2014;62(8):735-43. PubMed PMID: 25087625. 2. Huang KC, Chen Z, Jiang Y, Akare S, Kolber-Simonds D, Condon K, Agoulnik S, Tendyke K, Shen Y, Wu KM, Mathieu S, Choi HW, Zhu X, Shimizu H, Kotake Y, Gerwick WH, Uenaka T, Woodall-Jappe M, Nomoto K. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016 Jun;15(6):1208-16. doi: 10.1158/1535-7163.MCT-15-0648. Epub 2016 Mar 29. PubMed PMID: 27196783. 3. Thornburg CC, Cowley ES, Sikorska J, Shaala LA, Ishmael JE, Youssef DT, McPhail KL. Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens. J Nat Prod. 2013 Sep 27;76(9):1781-8. doi: 10.1021/np4004992. Epub 2013 Sep 9. PubMed PMID: 24016099; PubMed Central PMCID: PMC3969888. 4. Masuda Y, Suzuki J, Onda Y, Fujino Y, Yoshida M, Doi T. Total synthesis and conformational analysis of apratoxin C. J Org Chem. 2014 Sep 5;79(17):8000-9. doi: 10.1021/jo501130b. Epub 2014 Aug 18. PubMed PMID: 25093538.