TargetMol

Anemonin (6CI)

Product Code:
 
TAR-T30048
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30048-5mg5mg£850.00
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Further Information

Bioactivity:
Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis progression.
CAS:
508-44-1
Formula:
C10H8O4
Molecular Weight:
192.17
Purity:
0.98
SMILES:
O=C1O[C@@]2(CC[C@@]22OC(=O)C=C2)C=C1

References

1. Wang Z, Huang J, Zhou S, Luo F, Xu W, Wang Q, Tan Q, Chen L, Wang J, Chen H, Chen L, Xie Y, Du X. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1?/NF-?B pathway. J Cell Mol Med. 2017 Dec;21(12):3231-3243. doi: 10.1111/jcmm.13227. Epub 2017 Jun 23. PubMed PMID: 28643466; PubMed Central PMCID: PMC5706500. 2. Xiao K, Cao ST, Jiao le F, Lin FH, Wang L, Hu CH. Anemonin improves intestinal barrier restoration and influences TGF-?1 and EGFR signaling pathways in LPS-challenged piglets. Innate Immun. 2016 Jul;22(5):344-52. doi: 10.1177/1753425916648223. Epub 2016 May 12. PubMed PMID: 27189428. 3. Jia D, Han B, Yang S, Zhao J. Anemonin alleviates nerve injury after cerebral ischemia and reperfusion (i/r) in rats by improving antioxidant activities and inhibiting apoptosis pathway. J Mol Neurosci. 2014 Jun;53(2):271-9. doi: 10.1007/s12031-013-0217-z. Epub 2014 Jan 21. PubMed PMID: 24443273. 4. Huang YH, Lee TH, Chan KJ, Hsu FL, Wu YC, Lee MH. Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. J Dermatol Sci. 2008 Feb;49(2):115-23. Epub 2007 Sep 4. PubMed PMID: 17766092.