TargetMol

Amidantel hydrochloride

Product Code:
 
TAR-T29979
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29979-5mg5mg£850.00
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TAR-T29979-50mg50mg£1,661.00
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TAR-T29979-100mg100mg£2,079.00
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Further Information

Bioactivity:
Amidantel hydrochloride is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms. Amidantel was well tolerated by all animals tested and did not show teratogenic effects.
CAS:
69884-15-7
Formula:
C13H20ClN3O2
Molecular Weight:
285.77
Purity:
0.98
SMILES:
Cl.COCC(=O)Nc1ccc(cc1)N=C(/C)N(C)C

References

1. Pejo E, Santer P, Jeffrey S, Gallin H, Husain SS, Raines DE. Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology. Anesthesiology. 2014 Aug;121(2):290-301. doi: 10.1097/ALN.0000000000000268. PubMed PMID: 24777068; PubMed Central PMCID: PMC4121658. 2. Bruder EA, Ball IM, Ridi S, Pickett W, Hohl C. Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. Cochrane Database Syst Rev. 2015 Jan 8;1:CD010225. doi: 10.1002/14651858.CD010225.pub2. Review. PubMed PMID: 25568981. 3. Liu HC, Zhu D, Wang C, Guan H, Li S, Hu C, Chen Z, Hu Y, Lin H, Lian QQ, Ge RS. Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells. PLoS One. 2015 Nov 10;10(11):e0139311. doi: 10.1371/journal.pone.0139311. eCollection 2015. PubMed PMID: 26555702; PubMed Central PMCID: PMC4640886. 4. Liu S, Zhang XP, Han NN, Lv S, Xiong JY. Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis. Environ Toxicol Pharmacol. 2015 May;39(3):1212-20. doi: 10.1016/j.etap.2015.04.014. Epub 2015 Apr 25. PubMed PMID: 25989534.