TargetMol

Altinicline

Product Code:
 
TAR-T29916
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29916-5mg5mg£850.00
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TAR-T29916-50mg50mg£1,661.00
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Quantity:
TAR-T29916-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Altinicline can bine with neuronal nicotinic acetylcholine receptors; SIB-1765F - fumarate.
CAS:
179120-92-4
Formula:
C12H14N2
Molecular Weight:
186.258
Purity:
0.98
SMILES:
CN1CCC[C@H]1c1cncc(c1)C#C

References

1. Cosford ND, Bleicher L, Vernier JM, Chavez-Noriega L, Rao TS, Siegel RS, Suto C, Washburn M, Lloyd GK, McDonald IA. Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist. Pharm Acta Helv. 2000 Mar;74(2-3):125-30. PubMed PMID: 10812948. 2. Rao TS, Adams PB, Correa LD, Santori EM, Sacaan AI, Reid RT, Cosford ND. Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist. Brain Res. 2008 Oct 9;1234:16-24. doi: 10.1016/j.brainres.2008.07.063. Epub 2008 Jul 28. PubMed PMID: 18692487. 3. Wagner FF, Comins DL. Expedient five-step synthesis of SIB-1508Y from natural nicotine. J Org Chem. 2006 Oct 27;71(22):8673-5. PubMed PMID: 17064057.