TargetMol

AK-135

Product Code:
 
TAR-T29792
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29792-5mg5mg£850.00
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Further Information

Bioactivity:
AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione.
CAS:
75397-64-7
Formula:
C17H20ClNO2
Molecular Weight:
305.8
Purity:
0.98
SMILES:
Cl.CC1=C(CN2CCCCC2)C(=O)c2ccccc2C1=O

References

1. Shneyvays V, Leshem D, Shmist Y, Zinman T, Shainberg A. Effects of menadione and its derivative on cultured cardiomyocytes with mitochondrial disorders. J Mol Cell Cardiol. 2005 Jul;39(1):149-58. PubMed PMID: 15893762. 2. Levin GS, Tremasova GIa, Kostova SV, Dregeris IaIa. [The mechanism of action of a synthetic derivative of 1,4-naphthoquinone on the respiratory chain of liver and heart mitochondria]. Biokhimiia. 1989 Oct;54(10):1630-7. Russian. PubMed PMID: 2574998.