TargetMol

A 70874

Product Code:
 
TAR-T29502
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29502-5mg5mg£850.00
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Further Information

Bioactivity:
A70874 has high selectivity and potency for cholecystokinin (CCK) a receptor.
CAS:
131449-37-1
Formula:
C45H55N7O10
Molecular Weight:
853.974
Purity:
0.98
SMILES:
CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C

References

1. Lin CW, Shiosaki K, Miller TR, Witte DG, Bianchi BR, Wolfram CA, Kopecka H, Craig R, Wagenaar F, Nadzan AM. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39(3):346-51. PubMed PMID: 1706470. 2. Lin CW, Bianchi BR, Miller TR, Witte DG, Wolfram CA. Both CCK-A and CCK -B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands. Am J Physiol. 1992 Jun;262(6 Pt 1):G1113-20. PubMed PMID: 1616041. 3. Bianchi BR, Miller TR, Witte DG, Lin CW. Novel CCK analogues and bombesin: a detailed analysis between phosphoinositide breakdown and high-dose inhibition of pancreatic enzyme secretion in three rodent species. J Pharmacol Exp Ther. 1994 Feb;268(2):996-1002. PubMed PMID: 7509394.