TargetMol

VU0422288

Product Code:
 
TAR-T29135
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29135-5mg5mg£377.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29135-50mg50mg£1,356.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29135-100mg100mg£2,022.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
VU0422288 is a positive allosteric modulator with EC50 values are 108, 146 and 125 nM for mGlu4, mGlu7 and mGlu8 respectively.
CAS:
1630936-95-6
Formula:
C17H11Cl2N3O2
Molecular Weight:
360.19
Purity:
0.98
SMILES:
Clc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1

References

1. Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. doi: 10.1021/cn500153z. Epub 2014 Oct 9. PubMed PMID: 25225882; PubMed Central PMCID: PMC4306484.