TargetMol

U-7524

Product Code:
 
TAR-T29033
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29033-5mg5mg£850.00
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Quantity:
TAR-T29033-50mg50mg£1,661.00
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Quantity:
TAR-T29033-100mg100mg£2,079.00
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Further Information

Bioactivity:
U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes.
CAS:
645-88-5
Formula:
C2H5NO3
Molecular Weight:
91.066
Purity:
0.98
SMILES:
NOCC(O)=O

References

1. Carmona E, Gomes C, Trolin G. Effect of aminooxyacetic acid (AOAA) on GABA levels in some parts of the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1980 May;312(1):51-5. PubMed PMID: 7393347. 2. Duvilanski BH, Seilicovich A, D?az MC, Mu?oz Maines V, Lasaga M, Deb?ljuk L. Effect of GABA-T inhibitors on prolactin secretion in vitro. Eur J Pharmacol. 1985 Sep 10;115(1):65-9. PubMed PMID: 4043235. 3. Neal MJ, Starr MS. Effect of inhibitors of -aminobutyrate aminotransferase on the accumulation of 3H- -aminobutyric acid by the retina. Br J Pharmacol. 1973 Mar;47(3):543-55. PubMed PMID: 4730831; PubMed Central PMCID: PMC1776273. 4. van der Laan JW, Weick G, van Bleek G. Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature. Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate. Biochem Pharmacol. 1985 Nov 1;34(21):3789-94. PubMed PMID: 3933514.