TargetMol

Sm4

Product Code:
 
TAR-T28817
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28817-1mg1mg£227.00
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Quantity:
TAR-T28817-5mg5mg£416.00
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TAR-T28817-10mg10mg£581.00
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TAR-T28817-25mg25mg£863.00
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Quantity:
TAR-T28817-50mg50mg£1,163.00
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Quantity:
TAR-T28817-100mg100mg£1,540.00
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Quantity:
TAR-T28817-500mg500mg£3,026.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
Sm4 is a SOX18 blocker, suppressing genes downstream of the gene for Sox18 and interferring with vascular development. Sm4 has anti-metastatic and anti-cancer effects.
CAS:
365542-77-4
Formula:
C19H16O3
Molecular Weight:
292.334
Purity:
0.98
SMILES:
OC(=O)c1c(O)cccc1CCc1ccc2ccccc2c1

References

1. Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Hupp? CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette ?, Blanchet MR, Laplante M, Bourgoin SG, Boss? Y, Marsolais D. A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma. Front Pharmacol. 2017 Feb 21;8:78. doi: 10.3389/fphar.2017.00078. eCollection 2017. PubMed PMID: 28270767; PubMed Central PMCID: PMC5318459. 2. Kim I, Koh GY. Taking aim at Sox18. Elife. 2017 Jan 31;6. pii: e24238. doi: 10.7554/eLife.24238. PubMed PMID: 28137360; PubMed Central PMCID: PMC5283827. 3. Sahni N, Chaudhuri R, Hickey JM, Manikwar P, D'Souza A, Metters A, Joshi SB, Middaugh CR, Volkin DB. Preformulation Characterization, Stabilization, and Formulation Design for the Acrylodan-Labeled Glucose-Binding Protein SM4-AC. J Pharm Sci. 2017 May;106(5):1197-1210. doi: 10.1016/j.xphs.2017.01.004. Epub 2017 Jan 11. PubMed PMID: 28088457. 4. Hickey JM, Sahni N, Chaudhuri R, D'Souza A, Metters A, Joshi SB, Russell Middaugh C, Volkin DB. Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability, and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor. Protein Sci. 2017 Mar;26(3):527-535. doi: 10.1002/pro.3102. Epub 2017 Feb 12. PubMed PMID: 27997712; PubMed Central PMCID: PMC5326553.