TargetMol

SKI2496

Product Code:
 
TAR-T28795
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28795-5mg5mg£1,171.00
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TAR-T28795-50mg50mg£2,303.00
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Quantity:
TAR-T28795-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h)= 84%, 12h; LH inh. (24h) = 76%.). SKI2496 exhibits more selective antagonistic activity toward the human GnRH receptors over the GnRHRs in monkeys and rats.
CAS:
1308378-95-1
Formula:
C35H36F7N5O5
Molecular Weight:
739.692
Purity:
0.98
SMILES:
Cc1c(N2CCN(Cc3ccc(o3)C(F)(F)F)CC2)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F

References

1. Kim SM, Lee M, Lee SY, Park E, Lee SM, Kim EJ, Han MY, Yoo T, Ann J, Yoon S, Lee J, Lee J. Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist. J Med Chem. 2016 Sep 27. [Epub ahead of print] PubMed PMID: 27608177.