TargetMol

Sibenadet hydrochloride

Product Code:
 
TAR-T28774
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28774-5mg5mg£1,251.00
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TAR-T28774-50mg50mg£2,464.00
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Quantity:
TAR-T28774-100mg100mg£3,283.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Sibenadet, a D2/beta2-agonist, is potential useful for the treatment of symptoms of chronic obstructive pulmonary disease.
CAS:
154189-24-9
Formula:
C22H29ClN2O5S2
Molecular Weight:
501.05
Purity:
0.98
SMILES:
Cl.Oc1ccc(CCNCCS(=O)(=O)CCCOCCc2ccccc2)c2sc(=O)[nH]c12

References

1. Bradley JP, Pickard CJ, Burley JC, Martin DR, Hughes LP, Cosgrove SD, Brown SP. Probing intermolecular hydrogen bonding in sibenadet hydrochloride polymorphs by high-resolution (1) H double-quantum solid-state NMR spectroscopy. J Pharm Sci. 2012 May;101(5):1821-30. doi: 10.1002/jps.23078. Epub 2012 Feb 22. PubMed PMID: 22359321. 2. Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, Thorne P, Young A. From libraries to candidate: the discovery of new ultra long-acting dibasic ??-adrenoceptor agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):689-95. doi: 10.1016/j.bmcl.2011.10.049. Epub 2011 Oct 20. PubMed PMID: 22079756. 3. Connolly S, Alcaraz L, Bailey A, Cadogan E, Christie J, Cook AR, Fisher AJ, Hill S, Humphries A, Ingall AH, Kane Z, Paine S, Pairaudeau G, Stocks MJ, Young A. Design-driven LO: the discovery of new ultra long acting dibasic ?2-adrenoceptor agonists. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4612-6. doi: 10.1016/j.bmcl.2011.05.097. Epub 2011 Jun 13. PubMed PMID: 21723724. 4. Newbold P, Sanders N, Reele SB. Lack of correlation between exercise and sibenadet-induced changes in heart rate corrected measurement of the QT interval. Br J Clin Pharmacol. 2007 Mar;63(3):279-87. Epub 2006 Sep 12. PubMed PMID: 17380588; PubMed Central PMCID: PMC2000729.