TargetMol

SGE-516

Product Code:
 
TAR-T28766
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28766-5mg5mg£850.00
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  • Further Information
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Further Information

Bioactivity:
SGE516 is a neuroactive steroid and a positive allosteric modulator of both gamma- and delta-containing GABAA receptors. SGE516 reduces neuronal firing rates and epileptiform activity in vitro. SGE-516 protects against acute seizures and reduces neuronal cell death.
CAS:
1430064-74-6
Formula:
C23H35N3O2
Molecular Weight:
385.552
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H](C(=O)Cn3nccn3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@](C)(O)CC[C@]12[H]

References

1. Hammond RS, Althaus AL, Ackley MA, Maciag C, Martinez Botella G, Salituro FG, Robichaud AJ, Doherty JJ. Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models. Epilepsy Res. 2017 Aug;134:16-25. doi: 10.1016/j.eplepsyres.2017.05.001. Epub 2017 May 7. PubMed PMID: 28521115. 2. Althaus AL, McCarren HS, Alqazzaz A, Jackson C, McDonough JH, Smith CD, Hoffman E, Hammond RS, Robichaud AJ, Doherty JJ. The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication. Epilepsy Behav. 2017 Mar; 68:22-30. doi: 10.1016/j.yebeh.2016.12.024. Epub 2017 Jan 18. PubMed PMID: 28109985. 3. Martinez Botella G, Salituro FG, Harrison BL, Beresis RT, Bai Z, Shen K, Belfort GM, Loya CM, Ackley MA, Grossman SJ, Hoffmann E, Jia S, Wang J, Doherty JJ, Robichaud AJ. Neuroactive Steroids. 1. Positive Allosteric Modulators of the (?-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21. J Med Chem. 2015 Apr 23;58(8):3500-11. doi: 10.1021/acs.jmedchem.5b00032. Epub 2015 Apr 14. PubMed PMID: 25799373. 4. Modgil A, Parakala ML, Ackley MA, Doherty JJ, Moss SJ, Davies PA. Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism. Neuropharmacology. 2017 Feb;113(Pt A):314-322. doi: 10.1016/j.neuropharm.2016.10.010. Epub 2016 Oct 12. PubMed PMID: 27743930; PubMed Central PMCID: PMC5148695.