TargetMol

SCH-486757

Product Code:
 
TAR-T28728
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T28728-5mg5mg£850.00
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TAR-T28728-50mg50mg£1,661.00
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TAR-T28728-100mg100mg£2,079.00
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Further Information

Bioactivity:
SCH-486757, a nociceptin receptor (NOP) agonist, is used potentially for the treatment of cough.
CAS:
524019-25-8
Formula:
C24H23Cl2N3O
Molecular Weight:
440.37
Purity:
0.98
SMILES:
O[C@]1(C[C@@H]2CC[C@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ncccn1

References

1. McLeod RL, Tulshian DB, Bolser DC, Varty GB, Baptista M, Fernandez X, Parra LE, Zimmer JC, Erickson CH, Ho GD, Jia Y, Ng FW, Korfmacher W, Xu X, Veals J, Smith-Torhan A, Wainhaus S, Fawzi AB, Austin TM, van Heek M, Hey JA. Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20. doi: 10.1016/j.ejphar.2009.12.003. PubMed PMID: 20006596; PubMed Central PMCID: PMC2922759. 2. Enright BP, McIntyre BS, Barat SA, Treinen KA, Kopytek SJ. Effects of SCH 486757, a nociceptin-1 receptor agonist, on fertility and reproductive hormone levels in female CRL:CD?[SD] rats. Birth Defects Res B Dev Reprod Toxicol. 2012 Feb;95(1):12-22. doi: 10.1002/bdrb.20334. PubMed PMID: 21922640. 3. Penner NA, Ho G, Bercovici A, Chowdhury SK, Alton KB. Identification of two novel metabolites of SCH 486757, a nociceptin/orphanin FQ peptide receptor agonist, in humans. Drug Metab Dispos. 2010 Nov;38(11):2067-74. doi: 10.1124/dmd.110.032516. PubMed PMID: 20671096. 4. McLeod RL, Tulshian DB, Sadeh J. Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757. Pharmacology. 2011;88(1-2):50-4. doi: 10.1159/000328782. Review. PubMed PMID: 21757975.