TargetMol

SB 649915

Product Code:
 
TAR-T28678
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28678-5mg5mg£1,171.00
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TAR-T28678-50mg50mg£2,303.00
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Quantity:
TAR-T28678-100mg100mg£3,042.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist.
CAS:
420785-70-2
Formula:
C26H29N3O3
Molecular Weight:
431.536
Purity:
0.98
SMILES:
Cc1ccc2c(OCCN3CCC(Cc4ccc5OCC(=O)Nc5c4)CC3)cccc2n1

References

1. Watson JM, Dawson LA. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS Drug Rev. 2007 Summer;13(2):206-23. Review. PubMed PMID: 17627673. 2. Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test. Neuropsychopharmacology. 2007 Oct;32(10):2163-72. Epub 2007 Mar 14. PubMed PMID: 17356576. 3. Hughes ZA, Starr KR, Scott CM, Newson MJ, Sharp T, Watson JM, Hagan JJ, Dawson LA. Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B. Psychopharmacology (Berl). 2007 May;192(1):121-33. Epub 2007 Jan 30. PubMed PMID: 17265079. 4. Scott C, Soffin EM, Hill M, Atkinson PJ, Langmead CJ, Wren PB, Faedo S, Gordon LJ, Price GW, Bromidge S, Johnson CN, Hagan JJ, Watson J. SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue. Eur J Pharmacol. 2006 Apr 24;536(1-2):54-61. Epub 2006 Feb 28. PubMed PMID: 16571351.