TargetMol

SB 272183

Product Code:
 
TAR-T28677
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28677-5mg5mg£850.00
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Quantity:
TAR-T28677-50mg50mg£1,661.00
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Quantity:
TAR-T28677-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
SB 272183 is a highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drug.
CAS:
216058-27-4
Formula:
C29H28ClN5O
Molecular Weight:
498.03
Purity:
0.98
SMILES:
CN1CCN(CC1)c1cc2N(CCc2cc1Cl)C(=O)Nc1ccc(-c2ccncc2)c2ccccc12

References

1. Kling A, Lange UE, Mack H, Bakker MH, Drescher KU, Hornberger W, Hutchins CW, M?ller A, M?ller R, Schmidt M, Unger L, Wicke K, Schellhaas K, Steiner G. Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5567-73. Epub 2005 Oct 10. PubMed PMID: 16219465. 2. Wyman PA, Marshall HR, Flynn ST, King RJ, Thompson M, Smith PW, Hadley MS, Price GW, Scott CM, Dawson LA. Identification of a potent and selective 5-HT1B receptor antagonist. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4708-12. PubMed PMID: 16153839. 3. Watson J, Roberts C, Scott C, Kendall I, Collin L, Day NC, Harries MH, Soffin E, Davies CH, Randall AD, Heightman T, Gaster L, Wyman P, Parker C, Price GW, Middlemiss DN. SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol. 2001 Jul;133(6):797-806. PubMed PMID: 11454652; PubMed Central PMCID: PMC1572841.