TargetMol

SB 201146

Product Code:
 
TAR-T28667
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28667-5mg5mg£1,332.00
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Quantity:
TAR-T28667-50mg50mg£2,625.00
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Quantity:
TAR-T28667-100mg100mg£3,524.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SB 201146 is a leukotriene B4 antagonist with high affinity.
CAS:
141311-11-7
Formula:
C30H35LiN2O5S
Molecular Weight:
542.62
Purity:
0.98
SMILES:
[Li+].COc1ccc(CCCCCCCCOc2ccc(CS(=O)c3cccc(N)c3)nc2C=CC([O-])=O)cc1

References

1. Beeh KM, Kornmann O, Buhl R, Culpitt SV, Giembycz MA, Barnes PJ. Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest. 2003 Apr;123(4):1240-7. PubMed PMID: 12684317. 2. Lee E, Robertson T, Smith J, Kilfeather S. Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals. Am J Respir Crit Care Med. 2000 Jun;161(6):1881-6. PubMed PMID: 10852761. 3. Lee E, Lindo T, Jackson N, Meng-Choong L, Reynolds P, Hill A, Haswell M, Jackson S, Kilfeather S. Reversal of human neutrophil survival by leukotriene B(4) receptor blockade and 5-lipoxygenase and 5-lipoxygenase activating protein inhibitors. Am J Respir Crit Care Med. 1999 Dec;160(6):2079-85. PubMed PMID: 10588632. 4. Salmon M, Walsh DA, Huang TJ, Barnes PJ, Leonard TB, Hay DW, Chung KF. Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats. Br J Pharmacol. 1999 Jul;127(5):1151-8. PubMed PMID: 10455261; PubMed Central PMCID: PMC1566132.