TargetMol

RWJ 676070

Product Code:
 
TAR-T28629
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28629-5mg5mg£1,251.00
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TAR-T28629-50mg50mg£2,464.00
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Quantity:
TAR-T28629-100mg100mg£3,283.00
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  • Further Information
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Further Information

Bioactivity:
RWJ 676070 is an antagonist of vasopressin V1A/V2 receptor.
CAS:
813426-25-4
Formula:
C19H23FN2O3
Molecular Weight:
346.4
Purity:
0.98
SMILES:
O=C1N(C)C(CC12CCN(CCCC(C3=CC=C(F)C=C3)=O)CC2)=O

References

1. Coltamai L, Bucher M, Maillard MP, Shukla U, Bohidar N, Haskell L, Bertelsen K, Fedgchin M, Vogt B, Burnier M. Vascular effects of RWJ-676070, a selective combined V1a/V2 vasopressin receptor antagonist. Clin Pharmacol Ther. 2009 Feb;85(2):145-8. doi: 10.1038/clpt.2008.217. PubMed PMID: 18987622. 2. Gunnet JW, Wines P, Xiang M, Rybczynski P, Andrade-Gordon P, de Garavilla L, Parry TJ, Cheung WM, Minor L, Demarest KT, Maryanoff BE, Damiano BP. Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):333-42. doi: 10.1016/j.ejphar.2008.06.010. PubMed PMID: 18599033. 3. Xiang MA, Rybczynski PJ, Patel M, Chen RH, McComsey DF, Zhang HC, Gunnet JW, Look R, Wang Y, Minor LK, Zhong HM, Villani FJ, Demarest KT, Damiano BP, Maryanoff BE. Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6623-8. PubMed PMID: 17942308.