TargetMol

RO5353

Product Code:
 
TAR-T28603
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28603-5mg5mg£1,251.00
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TAR-T28603-50mg50mg£2,464.00
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Quantity:
TAR-T28603-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
RO5353 is a potent and orally active inhibitor of p53-MDM2.
CAS:
1360821-61-9
Formula:
C29H29Cl2FN4O4S
Molecular Weight:
619.53
Purity:
0.98
SMILES:
COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)sc21)C(N)=O

References

1. Zhang Z, Chu XJ, Liu JJ, Ding Q, Zhang J, Bartkovitz D, Jiang N, Karnachi P, So SS, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev L, Graves B. Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. doi: 10.1021/ml400359z. eCollection 2014 Feb 13. PubMed PMID: 24900784; PubMed Central PMCID: PMC4027646.