TargetMol

RA-839

Product Code:
 
TAR-T28497
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
RA-839 is a noncovalent small molecule binder of Keap1 and selective activator of Nrf2 signaling. RA-839 suppresses LPS-induced iNOS expression in macrophages.
CAS:
1832713-02-6
Formula:
C25H28N2O4S
Molecular Weight:
452.57
Purity:
0.98
SMILES:
Cc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccc(N2CC[C@@H](C2)C(O)=O)c2ccccc12

References

1. Nasiri HR, Linge S, Ullmann D. Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactions. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529. doi: 10.1016/j.bmcl.2015.11.082. Epub 2015 Nov 23. PubMed PMID: 26653613. 2. Winkel AF, Engel CK, Margerie D, Kannt A, Szillat H, Glombik H, Kallus C, Ruf S, G?ssregen S, Riedel J, Herling AW, von Knethen A, Weigert A, Br?ne B, Schmoll D. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J Biol Chem. 2015 Nov 20;290(47):28446-55. doi: 10.1074/jbc.M115.678136. Epub 2015 Oct 12. PubMed PMID: 26459563; PubMed Central PMCID: PMC4653701.