TargetMol

PS432

Product Code:
 
TAR-T28458
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28458-5mg5mg£324.00
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Quantity:
TAR-T28458-50mg50mg£1,042.00
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Quantity:
TAR-T28458-100mg100mg£1,540.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
PS432 is an allosteric inhibitor of atypical PKCs. PS432 targets the PIF-pocket resulting in significantly reduce tumor growth without side effects in mouse xenograft model.
CAS:
2083630-26-4
Formula:
C25H19ClN2O5S
Molecular Weight:
494.95
Purity:
0.98
SMILES:
CCOC(=O)C1=C(O)C(=O)N(C1c1ccc(o1)-c1ccc(Cl)cc1)c1nc2ccc(C)cc2s1

References

1. Arencibia JM, Fr?hner W, Krupa M, Pastor-Flores D, Merker P, Oellerich T, Neimanis S, Schmithals C, K?berle V, S?? E, Zeuzem S, Stark H, Piiper A, Odadzic D, Schulze JO, Biondi RM. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol. 2017 Feb 17;12(2):564-573. doi: 10.1021/acschembio.6b00827. Epub 2017 Jan 13. PubMed PMID: 28045490. 2. Arentz G, Chataway T, Condina MR, Price TJ, Hoffmann P, Hardingham JE. Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis. ISRN Mol Biol. 2012 Jan 31;2012:706545. doi: 10.5402/2012/706545. eCollection 2012. PubMed PMID: 27398237; PubMed Central PMCID: PMC4908239.