TargetMol

PD 140376

Product Code:
 
TAR-T28335
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28335-5mg5mg£1,813.00
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TAR-T28335-50mg50mg£3,589.00
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Quantity:
TAR-T28335-100mg100mg£4,970.00
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  • Further Information
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Further Information

Bioactivity:
PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems.
CAS:
149027-97-4
Formula:
C33H40N4O5
Molecular Weight:
572.706
Purity:
0.98
SMILES:
C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(O)=O)Cc1ccc(N)cc1

References

1. Hunter JC, Suman-Chauhan N, Meecham KG, Dissanayake VU, Hill DR, Pritchard MC, Kneen CO, Horwell DC, Hughes J, Woodruff GN. [3H]PD 140376: a novel and highly selective antagonist radioligand for the cholecystokininB/gastrin receptor in guinea pig cerebral cortex and gastric mucosa. Mol Pharmacol. 1993 Apr;43(4):595-602. PubMed PMID: 8474432. 2. Harper EA, Griffin EP, Shankley NP, Black JW. Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex. Br J Pharmacol. 1999 Mar;126(6):1496-503. PubMed PMID: 10217545; PubMed Central PMCID: PMC1565919. 3. Pinnock RD, Suman-Chauhan N, Daum P, Hill DR, Woodruff GN. The cholecystokinin-induced increase in intracellular calcium in AR42J cells is mediated by CCKB receptors linked to internal calcium stores. Neuropeptides. 1994 Sep;27(3):175-83. PubMed PMID: 7816188. 4. Harper EA, Shankley NP, Black JW. Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex. Br J Pharmacol. 1999 Mar;126(6):1504-12. PubMed PMID: 10217546; PubMed Central PMCID: PMC1565918.