TargetMol

PD 130883

Product Code:
 
TAR-T28326
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28326-5mg5mg£850.00
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Quantity:
TAR-T28326-50mg50mg£1,661.00
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Quantity:
TAR-T28326-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PD 130883 is a potent lipophilic quinazoline antifolate.
CAS:
123685-36-9
Formula:
C18H15N5O3
Molecular Weight:
349.35
Purity:
0.98
SMILES:
Nc1nc2ccc(CN(CC#C)c3ccc(cc3)[N+]([O-])=O)cc2c(=O)[nH]1

References

1. Seither RL, Trent DF, Mikulecky DC, Rape TJ, Goldman ID. Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition. J Biol Chem. 1991 Mar 5;266(7):4112-8. PubMed PMID: 1825652.