NC043

Product Code:

TAR-T28135

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T28135-5mg

5mg

£1,167.00

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Quantity:

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Further Information

Bioactivity:

NC043 is an inhibitor of Wnt/β-catenin signaling, it forms a covalent bond with the Cys-516 residue of CARF.

CAS:

1053172-87-4

Formula:

C22H30O4

Molecular Weight:

358.478

Purity:

0.98

SMILES:

C[C@@]12CCC[C@@]3([C@@H]1C[C@@H](O)[C@@]14CC[C@@H](C[C@@H]31)C(=C)C4=O)C(=O)COCC2

Documents

References

1. He X, Zhang W, Yan C, Nie F, Li C, Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W, Hao X, Li L. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/?-catenin transcriptional activity. Cell Discov. 2017 Jan 31;3:17003. doi: 10.1038/celldisc.2017.3. eCollection 2017. PubMed PMID: 28417011; PubMed Central PMCID: PMC5387711. 2. Wang W, Liu H, Wang S, Hao X, Li L. A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/?-catenin signaling and colon cancer cell tumorigenesis. Cell Res. 2011 May;21(5):730-40. doi: 10.1038/cr.2011.30. Epub 2011 Feb 15. PubMed PMID: 21321609; PubMed Central PMCID: PMC3203668.